O-GlcNAc Misregulation and Aneuploidy in Breast Cancer PRINCIPAL INVESTIGATOR:

NUCL EAR DNA CONTENT AND DNA PLOIDY ANALYSIS IN BREAST CANCER

To investigate the patterns of DNA ploidy and proliferating activity in breast cancer and relate them to other prognostic factors, paraffin blocks of 53 cases of breast carcinoma were studied. Cancer cells obtained by mechanical tissue disaggregation were examined for DNA content, ploidy and S-phase fraction. DNA assay was done using a CAS interactive image analyzing system. All of the cas...

AD AWARD NUMBER DAMD17-97-1-7144 TITLE: Tomosynthesis Breast Imaging: Early Detection and Characterization of Breast Cancer PRINCIPAL INVESTIGATOR:

AWARD NUMBER DAMD17-97-1-7144 TITLE: Tomosynthesis Breast Imaging: Early Detection and Characterization of Breast Cancer PRINCIPAL INVESTIGATOR: Loren T. Niklason, Ph.D. CONTRACTING ORGANIZATION: Massachusetts General Hospital Boston, Massachusetts 02114 REPORT DATE: July 1998 ^\$> TYPE OF REPORT: Annual "P^ PREPARED FOR: Commander U.S. Army Medical Research and Materiel Command Fort Detrick, M...

O-Linked N-Acetylglucosamine Cycling Regulates Mitotic Spindle Organization*

Any defects in the correct formation of the mitotic spindle will lead to chromosomal segregation errors, mitotic arrest, or aneuploidy. We demonstrate that O-linked N-acetylglucosamine (O-GlcNAc), a post-translational modification of serine and threonine residues in nuclear and cytoplasmic proteins, regulates spindle function. In O-GlcNAc transferase or O-GlcNAcase gain of function cells, the m...

Title Page Wen, Kuang-Yi Title of Project: MyHealthPortal: Using an Electronic Portal to Empower Patients with Breast Cancer Principal Investigator and Team Members: Principal Investigator

Bioinformatics-Based Prediction of FUT8 as a Therapeutic Target in Estrogen Receptor-Positive Breast Cancer

Abstract Introduction: Estrogen receptor-positive (ER-positive) breast cancer is a subgroup of breast tumors that is more likely to respond to hormone therapy. ER-positive and ER- negative breast cancers tend to show different patterns of metastasis because of different signaling cascade and genes that are activated by estrogen response. Genetic factors can contribute to high rates of metastas...